The oncogenic role and regulatory mechanism of ACAA2 in human ovarian cancer

• Published in: Molecular carcinogenesis Vol. 63; no. 7; pp. 1362 - 1377
• Main Authors: Leng, Yahui, Tian, Tian, Tang, Bingbing, Ma, Yongqing, Li, Zihang, Shi, Qin, Liu, Jiaqi, Zhou, Yang, Wang, Wenlong, Huang, Chengyang, Zhao, Xuan, Feng, Wenxiao, Liu, Yanni, Liang, Jingyin, Liu, Tianhui, Liu, Song, Ren, Qiulei, Liu, Jiakun, Zhang, Te, Zhou, Junsuo, Huang, Qian, Zhang, Yaling, Yin, Bin, Xu, Yuewen, Liu, Liaoyuan, Shen, Li, Zhao, Hongyan
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.07.2024
• Subjects: ACAA2; Bioinformatics; Cancer therapies; DIXDC1; Fatty acids; Gene expression; Glycosylation; glycosylation modification; Mitochondria; OGT; Oncogenes; Ovarian cancer; Oxidation; Signal transduction; Wnt protein; DIXDC1; ACAA2; OGT; glycosylation modification
• ISSN: 0899-1987; 1098-2744; 1098-2744
• DOI: 10.1002/mc.23729

Acetyl‐CoAacyltransferase2 (ACAA2) is a key enzyme in the fatty acid oxidation pathway that catalyzes the final step of mitochondrial β oxidation, which plays an important role in fatty acid metabolism. The expression of ACAA2 is closely related to the occurrence and malignant progression of tumors. However, the function of ACAA2 in ovarian cancer is unclear. The expression level and prognostic value of ACAA2 were analyzed by databases. Gain and loss of function were carried out to explore the function of ACAA2 in ovarian cancer. RNA‐seq and bioinformatics methods were applied to illustrate the regulatory mechanism of ACAA2. ACAA2 overexpression promoted the growth, proliferation, migration, and invasion of ovarian cancer, and ACAA2 knockdown inhibited the malignant progression of ovarian cancer as well as the ability of subcutaneous tumor formation in nude mice. At the same time, we found that OGT can induce glycosylation modification of ACAA2 and regulate the karyoplasmic distribution of ACAA2. OGT plays a vital role in ovarian cancer as a function of oncogenes. In addition, through RNA‐seq sequencing, we found that ACAA2 regulates the expression of DIXDC1. ACAA2 regulated the malignant progression of ovarian cancer through the WNT/β‐Catenin signaling pathway probably. ACAA2 is an oncogene in ovarian cancer and has the potential to be a target for ovarian cancer therapy. The proposed model underlying the roles of ACAA2 in human ovarian cancer