Transcutaneous auricular vagus nerve stimulation increases eye‐gaze on salient facial features and oxytocin release

• Published in: Psychophysiology Vol. 59; no. 11; pp. e14107 - n/a
• Main Authors: Zhu, Siyu, Qing, Yanan, Zhang, Yingying, Zhang, Xiaolu, Ding, Fangyuan, Zhang, Rong, Yao, Shuxia, Kendrick, Keith M., Zhao, Weihua
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.11.2022
• Subjects: Attention; Cognition; Cognition & reasoning; Electrical stimuli; Epilepsy; Eye; eye‐tracking; face emotion recognition; fixation duration; Motivation; Nose; Oxytocin; Saliva; Social interactions; transcutaneous auricular vagus nerve stimulation; Vagus nerve; Visual perception; oxytocin; eye-tracking; face emotion recognition; fixation duration; transcutaneous auricular vagus nerve stimulation
• ISSN: 0048-5772; 1469-8986; 1540-5958
• DOI: 10.1111/psyp.14107

Non‐invasive, transcutaneous electrical stimulation of the auricular branch of the vagus nerve (taVNS) via the ear is used therapeutically in epilepsy, pain, and depression, and may also have beneficial effects on social cognition. However, the underlying mechanisms of taVNS are unclear and evidence regarding its role in social cognition improvement is limited. To investigate the impact of taVNS on social cognition we have studied its effects on gaze toward emotional faces in combination with eye‐tracking and on the release of the neuropeptide oxytocin which plays a key role in influencing social cognition and motivation. A total of 54 subjects were enrolled (49 were included in the final analysis) in a sham‐controlled, participant‐blind, crossover experiment, consisting of two treatment sessions 1 week apart. In one session participants received 30‐min taVNS (tragus), and in the other, they received 30‐min sham (earlobe) stimulation with the treatment order counterbalanced. The proportion of time spent viewing the faces and facial features (eyes, nose, and mouth) was measured together with resting pupil size. Additionally, saliva samples were taken for the measurement of oxytocin concentrations by enzyme‐linked immunoassay. Saliva oxytocin concentrations increased significantly after taVNS compared to sham stimulation, while resting pupil size did not. In addition, taVNS increased time spent viewing the nose region irrespective of face emotion, and this was positively correlated with increased saliva oxytocin concentrations. Our findings suggest that taVNS biases visual attention toward socially salient facial features across different emotions and this is associated with its effects on increasing endogenous oxytocin release. Our findings elucidate the mechanism underlying the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on social cognition. We found that taVNS increased visual attention toward socially salient facial features across different emotions and this is associated with its effects on increasing endogenous oxytocin release, suggesting that taVNS may be a promising therapeutic treatment for disorders with social dysfunctions (i.e., autism spectrum disorder, schizophrenia, depression, and anxiety).