Effect of early membrane removal on regeneration of Class II furcation defects in dogs

• Published in: Journal of periodontology (1970) Vol. 77; no. 1; p. 46
• Main Authors: Macedo, Guilherme O, Souza, Sérgio L S, Novaes, Jr, Arthur B, Grisi, Marcio F M, Taba, Jr, Mário, Palioto, Daniela B
• Format: Journal Article
• Language: English
• Published: United States 01.01.2006
• Subjects: Alveolar Process - pathology; Animals; Bone Density - physiology; Bone Regeneration - physiology; Collagen; Connective Tissue - pathology; Dental Cementum - pathology; Dogs; Epithelium - pathology; Furcation Defects - pathology; Furcation Defects - surgery; Guided Tissue Regeneration, Periodontal - instrumentation; Membranes, Artificial; Periodontal Ligament - pathology; Polytetrafluoroethylene; Random Allocation; Regeneration - physiology; Surgical Flaps; Time Factors
• ISSN: 0022-3492
• DOI: 10.1902/jop.2006.77.1.46

This study evaluated the influence of early removal of an expanded polytetrafluoroethylene (ePTFE) membrane on periodontal regeneration. The third and fourth mandibular bicuspids of six healthy mongrel dogs were used. Class II furcation lesions were surgically created making lesions chronic for 21 days. Full flaps were elevated, and ePTFE membranes were adapted over the defects. The membranes were removed at 2 weeks on the experimental sides (test group [TGr]) and at 4 weeks on the control side (control group [CGr]). The dogs were sacrificed 12 weeks following placement of the membranes, and the teeth were histologically processed. Area measurements of new tissue (NT), epithelium (EP), connective tissue (CT), and new bone (NB) and linear measurements of bone height (BH) and new cementum (NC) were made. Wilcoxon signed rank test (P <0.05; N = 6) was carried out to determine differences between groups. The area measurements (in mm2) for TGr and CGr, respectively, were as follows: 14.32 +/- 4.01 and 12.46 +/- 3.54 (NT); 0.04 +/- 0.09 and 0.01 +/- 0.04 (EP); 2.31 +/- 2.60 and 1.91 +/- 2.96 (CT); and 9.56 +/- 3.77 and 8.79 +/- 2.99 (NB). The results of the linear measurements (in mm) for TGr and CGr, respectively, were as follows: 3.85 +/- 1.21 and 4.03 +/- 0.94 (BH) and 10.91 +/- 1.72 and 10.59 +/- 1.80 (NC). There were no statistically significant differences between TGr and CGr for any measurement. The early removal of ePTFE membranes in Class II furcation defects in dogs did not affect periodontal regeneration.