A Facile Method for the Preparation of Unsymmetrical Ureas Utilizing Zirconium(IV) Chloride

A facile synthetic method for the preparation of unsymmetrical ureas from amines is described. Carbamoyl imidazole compounds were prepared by the reaction of 1,1‐carbonyldiimidazole with primary or secondary amines, and further activation by treatment with zirconium(IV) chloride to generate the desi...

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Published inBulletin of the Korean Chemical Society Vol. 37; no. 2; pp. 154 - 160
Main Authors Lee, Anna, Kim, Hee-Kwon, Thompson, David H.
Format Journal Article
LanguageEnglish
Published Weinheim Wiley-VCH Verlag GmbH & Co. KGaA 01.02.2016
Wiley‐VCH Verlag GmbH & Co. KGaA
Wiley
대한화학회
Subjects
Carbamoyl imidazole
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
Unsymmetrical urea
Zirconium(IV) chloride
화학
HIV-1 PROTEASE INHIBITORS
Zirconium(IV) chloride
Unsymmetrical urea
ANALOGS
Carbamoyl imidazole
RECEPTOR
TETRASUBSTITUTED UREAS
DERIVATIVES
DISCOVERY
AMIDES
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Summary:A facile synthetic method for the preparation of unsymmetrical ureas from amines is described. Carbamoyl imidazole compounds were prepared by the reaction of 1,1‐carbonyldiimidazole with primary or secondary amines, and further activation by treatment with zirconium(IV) chloride to generate the desired urea. This reaction protocol was applied to the synthesis of tri and tetrasubstituted ureas with high yields. This study provides an alternative guideline for the practical preparation of various unsymmetrical ureas.
Bibliography:ArticleID:BKCS10646
istex:3183939B9E04684AD2E458BBBFDDD4A78A58FFAF
ark:/67375/WNG-4MPQDPJX-H
Ministry of Education - No. 2014R1A1A2057943
http://onlinelibrary.wiley.com/doi/10.1002/bkcs.10646/abstract
G704-000067.2016.37.2.016
ISSN:1229-5949
0253-2964
1229-5949
DOI:10.1002/bkcs.10646