Sweet's syndrome after splenic irradiation for chronic myelogenous leukemia

Sweet's syndrome is defined as acute febrile neutrophilic dermatosis. Characteristic features are fever; peripheral neutrophilia; and painful cutaneous nodules and plaques on the face, neck, trunk, and limbs. Biopsy specimens of these lesions show a mature neutrophilic infiltrate of the dermis....

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Bibliographic Details
Published inJournal of Osteopathic Medicine (Online) Vol. 96; no. 6; p. 366
Main Authors Pertusi, Raymond M., Forman, Mitchell D., Brown, Andrew C.
Format Journal Article
LanguageEnglish
Published United States American Osteopathic Association 01.06.1996
Subjects
Adult
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - complications
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - radiotherapy
Male
Radiodermatitis - pathology
Radiodermatitis - physiopathology
Spleen - radiation effects
Sweet Syndrome - etiology
Sweet Syndrome - pathology
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Summary:Sweet's syndrome is defined as acute febrile neutrophilic dermatosis. Characteristic features are fever; peripheral neutrophilia; and painful cutaneous nodules and plaques on the face, neck, trunk, and limbs. Biopsy specimens of these lesions show a mature neutrophilic infiltrate of the dermis. Vasculitis is absent. Sweet's syndrome is associated with malignancy in approximately 20% of reported cases. The pathogenesis is unknown. The authors describe Sweet's syndrome in a 39year-old man 5 weeks after splenic irradiation for chronic myelogenous leukemia. Treatment with parenteral corticosteroids resulted in dramatic improvement of the patient's condition. The authors discuss the diagnosis of Sweet's syndrome and the fact that it is thought to be cytokine-induced.
ISSN:0098-6151
2702-3648
2702-3648
1945-1997
DOI:10.7556/jaoa.1996.96.6.366