Recent progress on photodynamic therapy and photothermal therapy

• Published in: Bulletin of the Korean Chemical Society Vol. 44; no. 3; pp. 236 - 255
• Main Authors: Kim, Heejeong, Yang, Mengyao, Kwon, Nahyun, Cho, Moonyeon, Han, Jingjing, Wang, Rui, Qi, Sujie, Li, Haidong, Nguyen, Van‐Nghia, Li, Xingshu, Cheng, Hong‐Bo, Yoon, Juyoung
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley‐VCH Verlag GmbH & Co. KGaA 01.03.2023; 대한화학회
• Subjects: photodynamic therapy; photosensitizers; phototherapy; photothermal therapy; theranostics; 화학
• ISSN: 1229-5949; 0253-2964; 1229-5949
• DOI: 10.1002/bkcs.12655

Noninvasive treatments for terminal cancer patients constitute a new trend in tumor treatment. Therefore, phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), has attracted considerable interest. Light and a photosensitizer (PS) are employed in both treatment methods. For PDT, the PS generates reactive oxygen species (ROS) when exposed to light, whereas for PTT, the PS generates heat. In this regard, the systematic design of new PSs has become an active area of phototherapy research in an effort to solve the problems associated with conventional PSs. In the past decade, activatable and heavy‐atom‐free PSs have become significant research areas. Therefore, we discuss our recent contributions to the PDT and PTT in this account. Photodynamic therapy (PDT) and photothermal therapy (PTT) have attracted considerable interest as noninvasive treatment methods. Recent contributions to PDT and PTT are covered, emphasizing the development of new organic photosensitizers.