Analysis of glycosphingolipids of human head and neck carcinomas with comparison to normal tissue

Glycosphingolipids of head and neck carcinomas from six tumor-bearing patients were analyzed and compared to those of normal tissue from similar areas. The total glycosphingolipid content and the lipid-bound sialic acid were much higher in carcinomas than in normal tissue. Major neutral glycolipids...

Full description

Saved in:
Bibliographic Details
Published inBiochemistry and molecular biology international Vol. 46; no. 1; p. 125
Main Authors Bolot, G, David, M J, Taki, T, Handa, S, Kasama, T, Richard, M, Pignat, J C, Thomas, L, Portoukalian, J
Format Journal Article
LanguageEnglish
Published England 01.09.1998
Subjects
Biomarkers, Tumor - analysis
Chromatography, High Pressure Liquid
Gangliosides - analysis
Glycosphingolipids - analysis
Head and Neck Neoplasms - chemistry
Humans
Immunohistochemistry
Lipids - analysis
Mass Spectrometry
N-Acetylneuraminic Acid - analysis
Online AccessGet more information

Cover

More Information
Summary:Glycosphingolipids of head and neck carcinomas from six tumor-bearing patients were analyzed and compared to those of normal tissue from similar areas. The total glycosphingolipid content and the lipid-bound sialic acid were much higher in carcinomas than in normal tissue. Major neutral glycolipids were glucosylceramide, lactosylceramide, trihexosylceramide and paragloboside. Sulfatides were seen only in extracts from normal tissue which also showed a rather simple ganglioside pattern with #GM3 and GD3 as major species, whereas tumors showed additional species such as GM2 and GD2, along with a strong increase in LM1, GM1, GD1a and GT1b.
ISSN:1039-9712
DOI:10.1080/15216549800203632