Antitumor activity of conjugates of the oncofetal protein alpha-fetoprotein and phthalocyanines in vitro

• Published in: Biochemistry and molecular biology international Vol. 43; no. 4; p. 873
• Main Authors: Severin, S E, Posypanova, G A, Katukov, V U, Shmyrev, I I, Luzhkov YuM, Gerasimova, G K, Zhukova, O S, Vorozhtsov, G N, Kaliya, O L, Lukyanets, E A, Severin, E S
• Format: Journal Article
• Language: English
• Published: England 01.11.1997
• Subjects: alpha-Fetoproteins - pharmacology; alpha-Fetoproteins - toxicity; Aluminum - toxicity; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - pharmacology; Antineoplastic Agents - toxicity; Cobalt - toxicity; Female; Humans; Immunotoxins - pharmacology; Immunotoxins - toxicity; Indoles - pharmacology; Indoles - toxicity; Leukocytes, Mononuclear - drug effects; Neuroblastoma; Organometallic Compounds - toxicity; Ovarian Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured
• ISSN: 1039-9712
• DOI: 10.1080/15216549700204681

The several conjugates of aluminium and cobalt complexes of phthalocyanines with human alpha-fetoprotein have been synthesized. Their cytotoxic activity against tumor cells and human peripheral blood lymphocytes was studied. The experimental data demonstrate that the cytotoxic activity of alpha-fetoprotein-phthalocyanine conjugates against three types of tumor cells of various origin is much higher (for aluminium and cobalt complexes more than 1000 and 50 times, respectively) in comparison with phthalocyanines themselves. The application of phthalocyanines as conjugates with alpha-fetoprotein makes it possible to markedly enhance the selective toxicity of phthalocyanines against human tumor cells.