Periodontitis associated with Papillon-Lefèvre syndrome

The predominant subgingival microflora, host immune response, and genetic history of a 14-year-old girl with Papillon-Lefèvre Syndrome (PLS) are reported. The patient had high counts of Actinobacillus actinomycetemcomitans and surface translocating bacteria. She had significantly raised levels of an...

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Bibliographic Details
Published inJournal of periodontology (1970) Vol. 61; no. 6; p. 373
Main Authors Bimstein, E, Lustmann, J, Sela, M N, Neriah, Z B, Soskolne, W A
Format Journal Article
LanguageEnglish
Published United States 01.06.1990
Subjects
Actinobacillus - immunology
Actinobacillus - isolation & purification
Adolescent
Antibodies, Bacterial - analysis
Bacteroides - isolation & purification
Dental Plaque - microbiology
Female
Humans
Keratoderma, Palmoplantar - complications
Neutrophils - cytology
Neutrophils - metabolism
Papillon-Lefevre Disease - blood
Papillon-Lefevre Disease - complications
Papillon-Lefevre Disease - microbiology
Periodontitis - etiology
Superoxides - pharmacokinetics
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Summary:The predominant subgingival microflora, host immune response, and genetic history of a 14-year-old girl with Papillon-Lefèvre Syndrome (PLS) are reported. The patient had high counts of Actinobacillus actinomycetemcomitans and surface translocating bacteria. She had significantly raised levels of antibodies to five of the bacterial species studied with the levels to A. actinomycetemcomitans remaining high after antibiotic therapy. The polymorphonuclear leukocytes (PMN) also released significantly increased amounts of O2 compared to controls. The data presented support a role for A. actinomycetemcomitans and PMN dysfunction in the pathogenesis of PLS.
ISSN:0022-3492
DOI:10.1902/jop.1990.61.6.373