Cellular reprogramming for the creation of patient-specific embryonic stem cells

The success of somatic cell nuclear transfer in mammals has opened the possibility to dedifferentiate cells from a patient into embryonic stem cells and in doing so, potentially generate all different cells and tissues of the human body. These cells could be later transplanted to the same patient wi...

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Bibliographic Details
Published inStem cell reviews Vol. 2; no. 4; pp. 289 - 295
Main Authors Cibelli, Jose B, Kocabas, Arif M, Beyhan, Zeki, Ross, Pablo J
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.12.2006
Subjects
Animals
Cell Differentiation - physiology
Cell Fusion
Embryonic Stem Cells - physiology
Gene Expression Regulation
Humans
Laboratory animals
Nuclear Transfer Techniques
Oligonucleotide Array Sequence Analysis
Oocytes - physiology
Primates
Signal Transduction - physiology
Stem Cell Transplantation
Stem cells
Transforming Growth Factor beta - metabolism
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Summary:The success of somatic cell nuclear transfer in mammals has opened the possibility to dedifferentiate cells from a patient into embryonic stem cells and in doing so, potentially generate all different cells and tissues of the human body. These cells could be later transplanted to the same patient without immune rejection. Whereas this principle has been demonstrated in laboratory animals, it is yet to be shown to work in primates. Herein we discuss the probability of somatic cell nuclear transfer becoming a real therapeutic alternative as well as the potential emerging dedifferentiation approaches that may eventually replace it.
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ISSN:1550-8943
2629-3269
1558-6804
2629-3277
DOI:10.1007/BF02698055