Temperature regulates expression of the Drosophila vestigial gene only in mutant wing discs

All Vestigial mutants in Drosophila melanogaster display a thermosensitive phenotype, with the exception of two which disrupt an intronic wing-specific enhancer element. Here we report a very unusual transcriptional regulation; temperature changes are associated with alterations in the level of vg e...

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Bibliographic Details
Published inMolecular & general genetics Vol. 256; no. 3; pp. 328 - 332
Main Authors Silber, J, Flagiello, D, Cossard, R, Zider, A, Becker, J.L
Format Journal Article
LanguageEnglish
Published Germany 01.10.1997
Subjects
air temperature
Animals
Drosophila - genetics
Drosophila melanogaster
Drosophila Proteins
Enhancer Elements, Genetic
enhancer sequences
gene expression
Gene Expression Regulation
genes
Genes, Insect
genetic regulation
introns
larvae
messenger RNA
mutants
Mutation
Nuclear Proteins - genetics
Organ Specificity
phenotype
Temperature
transcription (genetics)
Transcription, Genetic
vg gene
wings
Wings, Animal
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Summary:All Vestigial mutants in Drosophila melanogaster display a thermosensitive phenotype, with the exception of two which disrupt an intronic wing-specific enhancer element. Here we report a very unusual transcriptional regulation; temperature changes are associated with alterations in the level of vg expression only in the wing disc of thermosensitive mutant flies and not in the brain. No effect is observed in the wild-type strain. The tissue specificity of the temperature effect indicates an involvement of the intronic wing-specific enhancer element in determining the thermosensitivity of mutants.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0026-8925
1432-1874
DOI:10.1007/s004380050576