MicroRNAs and their role on fish oxidative stress during xenobiotic environmental exposures
There is a growing global concern about the health implications of xenobiotics, which have harmful effects to both humans and wildlife. Among them, teleost fish are known as very sensitive to anthropogenic impacts, and are often being used as sentinel species in the aquatic environment. Xenobiotic m...
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Published in | Ecotoxicology and environmental safety Vol. 148; pp. 995 - 1000 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Inc
01.02.2018
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Subjects | |
Online Access | Get full text |
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Summary: | There is a growing global concern about the health implications of xenobiotics, which have harmful effects to both humans and wildlife. Among them, teleost fish are known as very sensitive to anthropogenic impacts, and are often being used as sentinel species in the aquatic environment. Xenobiotic molecules can alter the physiological homeostasis of fish and trigger an oxidative stress through overproduction of reactive oxygen species (ROS), suppressing the antioxidant system (AS) activity. An overwhelming generation of ROS is usually accompanied by damage to lipids, proteins and DNA structure, which can be associated with mutations, chromosomal aberrations and carcinogenesis. In particular, more attention has been paid lately to transcriptional and posttranscriptional regulation by several genes and microRNAs (miRNAs) related to AS after xenobiotic exposure in fish. Revealing these molecular mechanisms will help better understanding the processes of detoxification of xenobiotics and resistance to stress, and can also provide valuable information for estimating risk assessment of environmental pollution.
•Detoxification is important for understanding the different strategies of adaptation of fish.•The induction of the antioxidant enzymes represents early warning on living organisms.•MicroRNAs modulate oxidative stress in a feedback loops.•Study focus on the oxidative stress responses occurring from xenobiotics in fish. |
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ISSN: | 0147-6513 1090-2414 |
DOI: | 10.1016/j.ecoenv.2017.12.001 |