The prognostic value of radiomic features in liver-limited metastatic colorectal cancer patients from the TRIBE2 study
Evaluating the prognostic role of radiomic features in liver-limited metastatic colorectal cancer treated with first-line therapy at baseline and best response among patients undergoing resection. Among patients enrolled in TRIBE2 ( ), the association of clinical and radiomic data, extracted by SOPH...
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Published in | Future oncology (London, England) Vol. 19; no. 23; pp. 1601 - 1611 |
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Main Authors | , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Future Medicine Ltd
01.07.2023
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Subjects | |
Online Access | Get full text |
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Summary: | Evaluating the prognostic role of radiomic features in liver-limited metastatic colorectal cancer treated with first-line therapy at baseline and best response among patients undergoing resection.
Among patients enrolled in TRIBE2 (
), the association of clinical and radiomic data, extracted by SOPHiA-DDM™ with progression-free and overall survival (OS) in the overall population and with disease-free survival/postresection OS in those undergoing resection was investigated.
Among 98 patients, radiomic parameters improved the prediction accuracy of our model for OS (area under the curve: 0.83; sensitivity: 0.85; specificity: 0.73; accuracy: 0.78), but not progression-free survival. Of 46 resected patients, small-distance high gray-level emphasis was associated with shorter disease-free survival and high gray-level zone emphasis/higher kurtosis with shorter postresection OS.
Radiomic features should be implemented as tools of outcome prediction for liver-limited metastatic colorectal cancer.
In colorectal liver metastases, radiomics could be a valid tool for predicting prognosis in patients receiving first-line treatment and for stratification of patients based on the risk of relapse after curative resection. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1479-6694 1744-8301 |
DOI: | 10.2217/fon-2023-0406 |