ASSESSMENT OF CAMEL MILK YOGURT AS A COGENT APPROACH ON STREPTOZOTOCIN (STZ) INDUCED DIABETES MELLITUS IN SPRAGUE - DAWLEY RATS

• Published in: Journal of microbiology, biotechnology and food sciences Vol. 9; no. 3; pp. 648 - 652
• Main Authors: Khaliq, Adnan, Zahoor, Tahir, Nadeem, Muhammad, Imran, Muhammad, Amir Gilani, Syed, Farhan Jahangir Chughtai, Muhammad, Bilal Irshad, Muhammad, Liaqat, Atif, Pasha, Imran, Ahsan, Samreen, Shah, Faiz-ul-Hassan, Ali Shariati, Mohammad, Yessimbekov, Zhanibek
• Format: Journal Article
• Language: English
• Published: Nitra Faculty of Biotechnology and Food Sciences 01.12.2019
• Subjects: Beta cells; Biochemical markers; Clinical trials; Coagulation; Cow's milk; Diabetes; Diabetes mellitus; Diabetes mellitus (insulin dependent); Dietary supplements; Fermented milk products; Glucose; Immunoglobulins; Insulin; Kidneys; Metabolic disorders; Milk; Reduction; Streptozocin; Yogurt
• ISSN: 1338-5178; 1338-5178
• DOI: 10.15414/jmbfs.2019/20.9.3.648-652

According to Global report of World Health Organization (WHO) on diabetes, a predictable frequency of diabetes in the grown-up populace has nearly elevated 2-fold since 1980 from 4.7% to 8.5%. Altogether, mainstream of individuals is suffering from Type 1 diabetes mellitus of all diabetes cases which is a serious metabolic disorder and frightening state of cases booming annually. Camel milk, fresh/ fermented has the properties to be acknowledging for its potential effect for the cure of diabetes mellitus type 1. The higher concentration of insulin/insulin mimics particles in camel milk, like half cysteine, small sized immunoglobulins and their optimistic impact on beta cells and resistance to coagulation in acidic environment of stomach contributes to hypoglycemic effect in type 1 diabetes. The persistence of this study was the evaluation of camel milk yogurt on experimental Sprague-Dawley rats for type 1 diabetes. Two types of studies were conducted with four groups depending upon the diet. The analysis of serum glucose, insulin levels, liver and kidney functioning tests, and hematological analysis were performed to access the therapeutic potential of camel milk yogurt during efficacy trials. Serum glucose and insulin results showed that camel milk yogurt exhibited 3.69 % reduction of serum glucose level in study-I (fed on cow milk yogurt) whereas, 13.88% reduction was reported in study-II (fed on camel milk yogurt). Insulin concentration was increased 1.84 % in study-I whereas, 15.22 % was increased in study-II. Categorically, insulin percentage increment enlightened that induction of camel milk yogurt to subjects revealed better results in comparison to cow milk yogurt. The protective perspectives of camel milk yogurt supplementation to rats did not impart any deleterious effect on biochemical markers of the rats. Overall research showed that camel milk yogurt administration improved the clinical symptoms of diabatic rats along with minimal determental effects on health stratum of rats group.