Regional Skeletal Bone Deficit in Female Adolescents with Anorexia Nervosa: Influence of the Degree of Malnutrition and Weight Recovery in a Two Year Longitudinal Study
To analyze changes in bone mineral density (BMD) and the effect of weight recovery on the restoration of bone mass in adolescent females with anorexia nervosa (AN) with moderate malnutrition. We evaluated lumbar and femoral BMD in 27 females with restrictive AN with malnutrition and amenorrhea for o...
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Published in | Journal of Pediatric Endocrinology and Metabolism Vol. 20; no. 11; pp. 1223 - 1232 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Germany
De Gruyter
01.11.2007
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Subjects | |
Online Access | Get full text |
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Summary: | To analyze changes in bone mineral density (BMD) and the effect of weight recovery on the restoration of bone mass in adolescent females with anorexia nervosa (AN) with moderate malnutrition.
We evaluated lumbar and femoral BMD in 27 females with restrictive AN with malnutrition and amenorrhea for over (M+PA) or less than (M+SA) one year and 12 with normal nutrition and amenorrhea for over one year (N+PA) followed for 24 months.
BMI remained below -1.5 SD in M+PA and increased at 24 months in M+SA. M+PA had low lumbar and femoral neck BMD at diagnosis, decreasing at 24 months. Lumbar BMD in N+PA and M+SA was reduced, with an increase in M+SA at 24 months.
Moderate malnutrition in AN induces loss of bone mass at the lumbar and femoral levels. Weight gain and resumption of menses increases bone mass, especially in the lumbar spine. |
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Bibliography: | ark:/67375/QT4-Q6LNFH37-3 ArticleID:JPEM.2007.20.11.1223 jpem.2007.20.11.1223.pdf istex:523C1DE8D1A8E67F157D4DA1D18F49F9D6860309 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0334-018X 2191-0251 |
DOI: | 10.1515/JPEM.2007.20.11.1223 |