Foregut carcinoids: A clinical and biochemical analysis

• Published in: Surgery Vol. 126; no. 6; pp. 1105 - 1110
• Main Authors: Kirshbom, Paul M., Kherani, Aftab R., Onaitis, Mark W., Hata, Ankie, Kehoe, Theresa E., Feldman, Carol, Feldman, Jerome M., Tyler, Douglas S.
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 01.12.1999
• Subjects: Adult; Age Distribution; Aged; Analysis of Variance; Carcinoid Tumor - chemistry; Carcinoid Tumor - diagnosis; Carcinoid Tumor - mortality; Duodenal Neoplasms - chemistry; Duodenal Neoplasms - diagnosis; Duodenal Neoplasms - mortality; Female; Gastrointestinal Neoplasms - chemistry; Gastrointestinal Neoplasms - diagnosis; Gastrointestinal Neoplasms - mortality; Humans; Hydroxyindoleacetic Acid - blood; Male; Middle Aged; Pancreatic Neoplasms - chemistry; Pancreatic Neoplasms - diagnosis; Pancreatic Neoplasms - mortality; Retrospective Studies; Serotonin - blood; Sex Distribution; Stomach Neoplasms - chemistry; Stomach Neoplasms - diagnosis; Stomach Neoplasms - mortality; Survival Analysis
• ISSN: 0039-6060; 1532-7361
• DOI: 10.1067/msy.2099.101430

Background: Gastrointestinal foregut carcinoids make up a small percentage (3% to 6%) of all reported carcinoids. Because these tumors are so uncommon, comparisons between the subtypes have been difficult. The goal of this study was to compare the hormonal and clinical characteristics of gastric, duodenal, and pancreatic carcinoids. Methods: A prospective database of approximately 750 carcinoid patients seen by one author over 25 years was reviewed, and the 104 patients with gastric (33), duodenal (17), or pancreatic (54) carcinoids were selected as the subgroup for analysis. These patients were compared with regard to hormone levels, clinical course, treatment, and survival. Results: Duodenal carcinoids exhibited significantly lower serotoninergic hormone levels than did the gastric and pancreatic carcinoids (urine 5-hydroxyindoleacetic acid [mg/24 h], 5 ± 1 vs 16 ± 5 and 47 ± 12, respectively, P = .03). Pancreatic carcinoids presented with more advanced stage (distant metastases 87% vs 42% and 20% for gastric and duodenal, respectively) and had worse outcomes than patients with gastric and duodenal tumors with 10-year survivals of 10%, 59%, and 58%, respectively ( P = .003). Conclusions: Pancreatic carcinoids produce higher levels of serotoninergic hormones and have a significantly higher stage and worse outcome than other foregut carcinoids. This study demonstrates that the organ of origin is an important determinant of hormonal activity and clinical course for patients with foregut carcinoids. (Surgery 1999;126:1105--10.)