Allelic and haplotype frequencies of the p53 polymorphisms in brain tumor patients

The polymorphisms of the tumor suppressor gene p53 in exon 4 (p53 BstUI) and in intron 6 (p53 MspI) have been suggested to be associated with the genetically determined susceptibility in diverse types of human cancer. In our hospital-based case-control study, we examined the allele and genotype inci...

Full description

Saved in:
Bibliographic Details
Published inPhysiological research Vol. 51; no. 1; pp. 59 - 64
Main Authors Biros, E, Kalina, I, Kohút, A, Bogyiová, E, Salagovic, J, Sulla, I
Format Journal Article
LanguageEnglish
Published Czech Republic 2002
Subjects
Adult
Aged
Alleles
Brain Neoplasms - genetics
Electrophoresis, Polyacrylamide Gel
Female
Gene Frequency
Genes, p53 - genetics
Genotype
Haplotypes
Humans
Logistic Models
Male
Middle Aged
Odds Ratio
Polymorphism, Genetic - genetics
Online AccessGet full text

Cover

More Information
Summary:The polymorphisms of the tumor suppressor gene p53 in exon 4 (p53 BstUI) and in intron 6 (p53 MspI) have been suggested to be associated with the genetically determined susceptibility in diverse types of human cancer. In our hospital-based case-control study, we examined the allele and genotype incidence of these polymorphisms as well as their haplotype combinations in 60 brain tumor patients (27 males and 33 females) and 183 controls without malignancies. The genotype characteristics were determined by the PCR-based RFLP method using DNA extracted from peripheral blood. In this study we show that the p53 BstUI and the p53 MspI polymorphisms are not associated with increased risk of brain tumors. Thus, we conclude that the p53 BstUI and the p53 MspI polymorphic sites within the tumor suppressor gene p53 do not represent genetic determinants of susceptibility to brain tumors.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0862-8408
1802-9973
DOI:10.33549/physiolres.930134