Non-neoplastic lesions of female virgin Han: NMRI mice, incidence and influence of food restriction throughout life span. II. Respiratory tract

• Published in: Laboratory animals (London) Vol. 19; no. 3; pp. 224 - 235
• Main Authors: Rehm, S, Wcislo, A, Deerberg, F
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.07.1985
• Subjects: Animal Feed; Animals; Crystallography; Female; histopathology; longevity; Lung - pathology; Mice; Mice, Inbred Strains; mortality; Nasal Mucosa - pathology; Obesity; rats; respiratory tract diseases; Respiratory Tract Diseases - epidemiology; Respiratory Tract Diseases - pathology; Respiratory Tract Diseases - veterinary; restricted feeding; Rodent Diseases - epidemiology; Rodent Diseases - pathology; Species Specificity; Thinness; Trachea - pathology; DIET; RESPIRATORY TRACT DISEASE; MICE
• ISSN: 0023-6772; 1758-1117
• DOI: 10.1258/002367785780893629

A life-span study with 900 female virgin Han:NMRI mice (300 outbred controls, 300 of a fat subline and 300 of a lean subline) was carried out to determine the occurrence of spontaneous diseases with ad libitum or restricted feeding. Rare non-neoplastic lesions of the lungs (1-8%) were secondary inflammations, focal ossification and subintimal arterial 'plaques'. More frequent were age-dependent pulmonary mineralizations similar to psammoma bodies (3-18%) and crystal formations (4-22%). Food restriction did not affect the incidence of these lesions directly. Crystals were observed furthermore within infoldings of the tracheobronchial mucosa and intra- as well as extracellularly in the nasal cavities.