Gold nanoblackbodies mediated plasmonic photothermal cancer therapy for melanoma

• Published in: Nanomedicine (London, England) Vol. 17; no. 19; pp. 1323 - 1338
• Main Authors: Khurana, Divya, Dudi, Rajesh, Shukla, Sanket K, Singh, Deepika, Mondhe, Dilip Manikrao, Soni, Sanjeev
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.08.2022
• Subjects: Animals; cancer; Gold; gold nanoblackbodies; Infrared Rays; melanoma; Melanoma, Experimental - therapy; Mice; Mice, Inbred C57BL; near-infrared irradiation; Phototherapy; plasmonic photothermal therapy; polydopamine; melanoma; cancer; polydopamine; gold nanoblackbodies; near-infrared irradiation; plasmonic photothermal therapy
• ISSN: 1743-5889; 1748-6963
• DOI: 10.2217/nnm-2022-0052

Gold nanoblackbodies (AuNBs)-mediated plasmonic photothermal cancer therapy was investigated through melanoma-bearing mice. Polydopamine-coated Au nanoclusters were synthesized, termed AuNBs and PEGylated AuNBs (AuNBs-PEG). The photothermal response of AuNBs-PEG was evaluated upon low-intensity broadband near-infrared irradiation (785/62 nm; 0.9 Wcm ), and cytotoxicity was assessed on B16-F10 cells. Further, the therapeutic potential of intravenously administered AuNBs-PEG was evaluated on B16-F10 melanoma in C57BL/6 mice. AuNBs-PEG showed an excellent photothermal response (photothermal conversion efficiency of 60.3%), robust photothermal stability and no cytotoxicity. For AuNB-mediated plasmonic photothermal therapy, an average temperature of 63°C was attained within 5 min of irradiation, and tumors were eradicated. AuNBs-PEG are promising photothermal agents for treating melanoma through low-intensity broadband near-infrared irradiation.