Gold nanoblackbodies mediated plasmonic photothermal cancer therapy for melanoma
Gold nanoblackbodies (AuNBs)-mediated plasmonic photothermal cancer therapy was investigated through melanoma-bearing mice. Polydopamine-coated Au nanoclusters were synthesized, termed AuNBs and PEGylated AuNBs (AuNBs-PEG). The photothermal response of AuNBs-PEG was evaluated upon low-intensity broa...
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Published in | Nanomedicine (London, England) Vol. 17; no. 19; pp. 1323 - 1338 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Future Medicine Ltd
01.08.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Gold nanoblackbodies (AuNBs)-mediated plasmonic photothermal cancer therapy was investigated through melanoma-bearing mice.
Polydopamine-coated Au nanoclusters were synthesized, termed AuNBs and PEGylated AuNBs (AuNBs-PEG). The photothermal response of AuNBs-PEG was evaluated upon low-intensity broadband near-infrared irradiation (785/62 nm; 0.9 Wcm
), and cytotoxicity was assessed on B16-F10 cells. Further, the therapeutic potential of intravenously administered AuNBs-PEG was evaluated on B16-F10 melanoma in C57BL/6 mice.
AuNBs-PEG showed an excellent photothermal response (photothermal conversion efficiency of 60.3%), robust photothermal stability and no cytotoxicity. For AuNB-mediated plasmonic photothermal therapy, an average temperature of 63°C was attained within 5 min of irradiation, and tumors were eradicated.
AuNBs-PEG are promising photothermal agents for treating melanoma through low-intensity broadband near-infrared irradiation. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1743-5889 1748-6963 |
DOI: | 10.2217/nnm-2022-0052 |