Chitosan/PVA hydrogels incorporated with green synthesized cerium oxide nanoparticles for wound healing applications

• Published in: European polymer journal Vol. 134; p. 109853
• Main Authors: Kalantari, Katayoon, Mostafavi, Ebrahim, Saleh, Bahram, Soltantabar, Pooneh, Webster, Thomas J.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 05.07.2020; Elsevier BV
• Subjects: Antibacterial; Antibiotics; CeO2 nanoparticles; Cerium oxides; Chemical synthesis; Chitosan; E coli; Freeze-thaw; Ginger; Human dermal fibroblasts; Hydrogel; Hydrogels; MRSA; Nanoparticles; Polyvinyl alcohol; Wound healing; Human dermal fibroblasts; Wound healing; MRSA; CeO2 nanoparticles; Chitosan; Hydrogel; Antibacterial
• ISSN: 0014-3057; 1873-1945
• DOI: 10.1016/j.eurpolymj.2020.109853

[Display omitted] •CeO2-NPs synthesized using the Zingiber officinale extract as a green method.•CeO2-NPs were coated with an organic leaf extract forming small aggregates.•PVA/chitosan hydrogel loaded with CeO2-NPs evaluated for potential wound dressing.•Hydrogels showed enhanced cell compatibility and survival with addition of CeO2-NPs.•Hydrogels showed potent antibacterial activity against MRSA. In this paper, we report the synthesis and evaluation of a polyvinyl alcohol/chitosan (PVA/chitosan) hydrogel incorporated with green synthesized cerium oxide nanoparticles (CeO2-NPs) using a Zingiber officinale extract as the reducing, capping and stabilizer agent for wound healing applications. The PVA/chitosan/CeO2-NPs hydrogel was synthesized via the freeze-thaw technique with 0 to 1% (wt) 5 nm CeO2-NPs. Results revealed that the hydrogels containing 0.5% of CeO2-NPs showed better antibacterial activities after just 12 hr (with MRSA but not E. coli) and healthy human dermal fibroblast viabilities up to 5 days (more than 90%) compared to the control group. Therefore, these chitosan/PVA hydrogels incorporated with Ce-NPs could be a potential candidate as a robust wound dressing agent that impressively may decrease wound infections without resorting to the use of antibiotics.