RAB1A regulates glioma cellular proliferation and invasion via the mTOR signaling pathway and epithelial–mesenchymal transition
We aimed at investigating the mechanism of RAB1A proliferation and invasion in gliomas. Genome-wide expression profile data and immunohistochemistry were analyzed to assess expression in gliomas. The Transwell assay, wound healing assay, brain slice coculture model, cellular fluorescence and intracr...
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Published in | Future oncology (London, England) Vol. 17; no. 24; pp. 3203 - 3216 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Future Medicine Ltd
01.08.2021
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Subjects | |
Online Access | Get full text |
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Summary: | We aimed at investigating the mechanism of RAB1A proliferation and invasion in gliomas.
Genome-wide expression profile data and immunohistochemistry were analyzed to assess
expression in gliomas. The Transwell assay, wound healing assay, brain slice coculture model, cellular fluorescence and intracranial xenograft model of nude mice were used to determine the proliferation and invasion of glioma cells.
was highly expressed in gliomas compared with normal brain tissue. The overall survival time of glioma patients with high
expression was significantly shortened. RAB1A regulated the activity of RAC1 by inhibiting the mTOR signaling pathway, affecting actin polymerization, cell morphology and cell polarity.
downregulation inhibited the epithelial–mesenchymal transition, proliferation and invasion of glioma cells. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1479-6694 1744-8301 |
DOI: | 10.2217/fon-2021-0116 |