Tumor vascular heterogeneity and the impact of subtumoral nanoemulsion biodistribution

• Published in: Nanomedicine (London, England) Vol. 17; no. 27; pp. 2073 - 2088
• Main Authors: de Oliveira, Jaqueline Vaz, Oliveira da Rocha, Márcia Cristina, de Sousa-Junior, Ailton Antônio, Rodrigues, Mosar Corrêa, Farias, Gabriel Ribeiro, da Silva, Patrícia Bento, Bao, Sônia Nair, Bakuzis, Andris Figueiroa, Azevedo, Ricardo Bentes, Morais, Paulo César, Muehlmann, Luís Alexandre, Figueiró Longo, João Paulo
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.11.2022
• Subjects: biodistribution; breast cancer; breast cancer cell; Breast Neoplasms - diagnostic imaging; Cell Line, Tumor; Emulsions - chemistry; Female; Humans; imaging; Lipids; mathematical model; modeling; nanomedicine; Nanoparticles - chemistry; preclinical; Tissue Distribution; tumor model; biodistribution; in vivo imaging; modeling; tumor model; preclinical; mathematical model; breast cancer; nanomedicine; breast cancer cell
• ISSN: 1743-5889; 1748-6963
• DOI: 10.2217/nnm-2022-0176

Investigate the heterogeneous tumor tissue organization and examine how this condition can interfere with the passive delivery of a lipid nanoemulsion in two breast cancer preclinical models (4T1 and Ehrlich). The authors used image techniques to follow the nanoemulsion biodistribution and microtomography, as well as traditional histopathology and electron microscopy to evaluate the tumor structural characteristics. Lipid nanoemulsion was delivered to the tumor, vascular organization depends upon the subtumoral localization and this heterogeneous organization promotes a nanoemulsion biodistribution to the highly vascular peripherical region. Also, the results are presented with a comprehensive mathematical model, describing the differential biodistribution in two different breast cancer models, the 4T1 and Ehrlich models.