Recent progress in cationic polymeric gene carriers for cancer therapy

• Published in: Science China. Chemistry Vol. 60; no. 3; pp. 319 - 328
• Main Authors: Xu, Caina, Tian, Huayu, Chen, Xuesi
• Format: Journal Article
• Language: English
• Published: Beijing Science China Press 01.03.2017; Springer Nature B.V
• Subjects: Anticancer properties; Biomedical materials; Breast cancer; Cancer therapies; Cationic polymerization; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Chitosan; Cytotoxicity; Dendrimers; Efficiency; Gene therapy; Molecular weight; Physiology; Polyethylene glycol; Polyethyleneimine; Polymers; Reviews; Therapy; Toxicity; Tumors; Vectors (Biology); polymeric gene carriers; cancer therapy; multifunctional gene carriers; stimuli-responsive carriers
• ISSN: 1674-7291; 1869-1870
• DOI: 10.1007/s11426-016-0466-x

In recent years,various carriers for gene delivery nave been developed for biomedical applications.Among all kinds of gene carriers,cationic polymeric carriers for delivery therapeutic gene as non-viral carriers have received growing interests due to their improved high transfection efficiency with the relative safety.In particular,the advancement of novel polymeric gene carriers has gained much progress in the development of effective anticancer therapy.Herein,this review focused on the development of cationic polymeric carriers for cancer therapy,including polyethylenimine（PEI）,polyamidoamine（PAMAM） dendrimers,polylysine（PLL）,chitosan and modified cationic polymers.And recent progresses in the development of novel polymeric carriers for gene delivery,such as targeted gene carriers,responsive gene carriers and multifunctional gene carriers,were summarized.Finally,the future perspectives in the development of novel polymeric carriers for delivery gene were presented.