Optimal Design of Dose Response Experiments: A Model-Oriented Approach
We discuss optimal experimental design issues for nonlinear models arising in dose response studies. The optimization is performed with respect to various criteria which depend on the Fisher information matrix. Special attention is given to models with a variance component that depends on unknown pa...
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Published in | Drug information journal Vol. 35; no. 4; pp. 1373 - 1383 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Los Angeles, CA
SAGE Publications
01.10.2001
Pergamon Press Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | We discuss optimal experimental design issues for nonlinear models arising in dose response studies. The optimization is performed with respect to various criteria which depend on the Fisher information matrix. Special attention is given to models with a variance component that depends on unknown parameters. |
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ISSN: | 2168-4790 0092-8615 2168-4804 2164-9200 |
DOI: | 10.1177/009286150103500433 |