Marginal zinc status does not exacerbate pancreatic carcinogenesis associated with dietary soybean trypsin inhibitor concentrate in rats

Although the etiology of pancreatic cancer is largely unknown, diet-associated factors may play a role. Male Sprague-Dawley rats (14 d of age) were given a single injection of either saline or azaserine and were weaned (21 d) to diets with either adequate (30 microgram/g) or low (9 microgram/g) zinc...

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Bibliographic Details
Published inThe Journal of nutrition Vol. 124; no. 6; pp. 894 - 900
Main Authors Ellwood, K.C, Roebuck, B.D, Hathcock, J.N
Format Journal Article
LanguageEnglish
Published United States 01.06.1994
Subjects
ANATOMIA ANIMAL
ANATOMIE ANIMALE
Animals
ANTIBIOTICOS
ANTIBIOTIQUE
Azaserine - pharmacology
Body Weight - drug effects
CINC
Diet
DIETA
ESTADO NUTRICIONAL
ETAT NUTRITIONNEL
INHIBIDORES DE ENZIMAS
INHIBITEUR D'ENZYME
Male
NEOPLASMAS
NEOPLASME
Nutritional Status
Organ Size - drug effects
PANCREAS
Pancreatic Neoplasms - etiology
PESO
POIDS
RAT
RATA
Rats
Rats, Sprague-Dawley
REGIME ALIMENTAIRE
SERUM SANGUIN
SOJA
SUERO SANGUINEO
TRIPSINA
Trypsin Inhibitors - administration & dosage
Trypsin Inhibitors - toxicity
TRYPSINE
ZINC
Zinc - administration & dosage
Zinc - blood
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Summary:Although the etiology of pancreatic cancer is largely unknown, diet-associated factors may play a role. Male Sprague-Dawley rats (14 d of age) were given a single injection of either saline or azaserine and were weaned (21 d) to diets with either adequate (30 microgram/g) or low (9 microgram/g) zinc, with or without 1.0 g/100 g active trypsin inhibitor in the form of soybean trypsin inhibitor concentrate. Experimental diets were fed for 14 wk. Regardless of dietary zinc status, diets with soybean trypsin inhibitor concentrate caused hyperplasia and/or hypertrophy of the pancreas. Pancreatic zinc content was not different among groups. Low dietary zinc levels did not affect total body growth rate or serum zinc concentration. Tibia zinc was also used as an indicator of zinc status. Tibia zinc concentration was lower in rats fed diets low in zinc relative to adequate zinc diets. Azaserine-induced acidophilic foci were larger and more numerous when soybean trypsin inhibitor concentrate was present in the diet regardless of dietary zinc level. Thus, low zinc does not exacerbate the soybean trypsin inhibitor concentrate effects that promote pancreatic cancer
Bibliography:L74
9504927
ISSN:0022-3166
1541-6100
DOI:10.1093/jn/124.6.894