Nano-biopower supplies for biomolecular motors: the use of metabolic pathway-based fuel generating systems in microfluidic devices

We report fuel generation systems for molecular motors based on pyruvate kinase, or for the first time, mitochondria, implemented within microfluidic devices. Intact organelles acted as bio-nanopower supplies for molecular motors, using isolated mitochondria to convert chemical energy from succinate...

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Published inLab on a chip Vol. 8; no. 6; pp. 979 - 982
Main Authors Wasylycia, Joshua R, Sapelnikova, Svetlana, Jeong, Hyuk, Dragoljic, Jelena, Marcus, Sandra L, Harrison, D Jed
Format Journal Article
LanguageEnglish
Published England 01.01.2008
Subjects
Adenosine Triphosphate - chemistry
Adenosine Triphosphate - metabolism
Energy-Generating Resources
Microfluidic Analytical Techniques - instrumentation
Microfluidic Analytical Techniques - methods
Mitochondria - enzymology
Nanotechnology - instrumentation
Nanotechnology - methods
Pyruvate Kinase - chemistry
Pyruvate Kinase - metabolism
Succinic Acid - chemistry
Succinic Acid - metabolism
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Summary:We report fuel generation systems for molecular motors based on pyruvate kinase, or for the first time, mitochondria, implemented within microfluidic devices. Intact organelles acted as bio-nanopower supplies for molecular motors, using isolated mitochondria to convert chemical energy from succinate to ATP, harnessing nature's enzymatic transformation cascades directly. Motors were activated essentially equally by ATP produced by pyruvate kinase, mitochondria, or direct addition of ATP.
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ISSN:1473-0197
1473-0189
DOI:10.1039/b801033a