Cascade biomimetic intelligent nanotheranostic agents for imaging-guided tumor synergistic therapy

• Published in: Nanomedicine (London, England) Vol. 18; no. 1; pp. 35 - 52
• Main Authors: Fang, Zhengzou, Zhu, Ziyu, Zhuang, Zijian, Li, Zhangzuo, Yan, Cheng, Yang, Mengting, Chen, Qian, Li, Xinyuan, Gong, Aihua
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.01.2023
• Subjects: Biomimetics; Cell Line, Tumor; Doxorubicin - pharmacology; Doxorubicin - therapeutic use; environment-responsive; fluorescence; Humans; imaging-guided; Indocyanine Green - therapeutic use; Manganese Compounds; Nanoparticles; Neoplasms - diagnostic imaging; Neoplasms - drug therapy; Oxides; Theranostic Nanomedicine - methods; fluorescence; environment-responsive; imaging-guided
• ISSN: 1743-5889; 1748-6963
• DOI: 10.2217/nnm-2022-0266

Achieving drug-targeting delivery and environment-responsive releasing to realize imaging-guided precise tumor therapy. Graphene oxide (GO) was used as the drug-delivery system to load indocyanine green (ICG) and doxorubicin (DOX) to form a GO/ICG&DOX nanoplatform, in which GO can quench the fluorescence of ICG and DOX. MnO and folate acid-functionalized erythrocyte membrane were further coated into the surface of GO/ICG&DOX to obtain an FA-EM@MnO -GO/ICG&DOX nanoplatform. The FA-EM@MnO -GO/ICG&DOX nanoplatform has longer blood circulation time, precise targeting delivery to tumor tissues and catalase-like activity. Both and results demonstrated that the FA-EM@MnO -GO/ICG&DOX nanoplatform has better therapeutic efficacy. The authors successfully fabricated a glutathione-responsive FA-EM@MnO -GO/ICG&DOX nanoplatform, which can achieve drug-targeting delivery and precise drug release.