Targeted delivery of edaravone by liposomes for the treatment of ischemic stroke

To construct an edaravone-encapsulated liposomes (EDV-LIPs) formulation against acute ischemic stroke. EDV-LIPs were prepared by the film dispersion method. The biosafety was evaluated both and by flow cytometry and the histological staining method. Biodistribution and therapeutic effect of EDV-LIPs...

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Published inNanomedicine (London, England) Vol. 17; no. 11; pp. 741 - 752
Main Authors Song, Meng-Meng, Chen, Jing, Ye, Shu-Ming, Lu, Da-Peng, Zhang, Gui-Yang, Liu, Rui, Shen, Yu-Xian
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.05.2022
Subjects
drug delivery
edaravone
gene delivery
ischemic stroke
liposomes
nanomaterials
gene delivery
edaravone
nanomaterials
drug delivery
liposomes
ischemic stroke
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Summary:To construct an edaravone-encapsulated liposomes (EDV-LIPs) formulation against acute ischemic stroke. EDV-LIPs were prepared by the film dispersion method. The biosafety was evaluated both and by flow cytometry and the histological staining method. Biodistribution and therapeutic effect of EDV-LIPs against acute ischemic stroke was investigated by fluorescent imaging, the behavior test, laser speckle imaging and triphenyltetrazolium chloride staining. The nanoliposomes had a long circulation time and could accumulate in the brain lesion region in ischemic stroke rats. EDV-LIPs show good biosafety. EDV-LIPs could restore more cerebral blood flow, reduce infarct volume and decrease neuronal apoptosis. EDV-LIPs provide an effective alternative for drug-targeted delivery against acute ischemic stroke.
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ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2021-0490