The role of androgen receptors in vascular and cell proliferation of the prostate adenocarcinomas

Prostate adenocarcinoma (PA) is by incidence and prognosis a unique model for investigating the biomolecular mechanisms involved in tumor progression. In this study, we analyzed the immunoexpression of androgen receptor (AR), cluster of differentiation 105 (CD105) and Ki67 for 61 cases of PA, in rel...

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Bibliographic Details
Published inRomanian journal of morphology and embryology Vol. 61; no. 3; pp. 803 - 811
Main Authors Pănuş, Andrei, Mărgăritescu, Claudiu, Drăgoescu, Petru Octavian, Tomescu, Paul Ioan, Ştefănescu, Mihai Lucian, Stepan, Alex Emilian
Format Journal Article
LanguageEnglish
Published Romania Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 01.01.2020
Subjects
Adenocarcinoma
Biomarkers, Tumor
Cell Proliferation
Humans
Male
Original Paper
Prognosis
Prostatic Neoplasms
Receptors, Androgen
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Summary:Prostate adenocarcinoma (PA) is by incidence and prognosis a unique model for investigating the biomolecular mechanisms involved in tumor progression. In this study, we analyzed the immunoexpression of androgen receptor (AR), cluster of differentiation 105 (CD105) and Ki67 for 61 cases of PA, in relation to the main clinicopathological parameters of the lesions. The AR scores, CD105 microvessel density (MVD) and Ki67 proliferation index (PI) were significantly higher in patients with serum prostate-specific antigen (PSA) above 20 ng∕mL, in ductal, colloid and sarcomatoid types of PA, in growth patterns 4-5 or mixed, respectively in the case of high-grade advanced stage tumors, with perineural and vascular invasion, as well as in groups with a reserved prognosis. The results obtained, reflected in the positive linear correlation of AR, CD105 and Ki67 expression, indicate synchronous endocrine, angiogenic and proliferative mechanisms involved in tumor progression, which can be used to optimize the targeted tumor therapy.
ISSN:1220-0522
2066-8279
DOI:10.47162/RJME.61.3.18