Search for Ideal P-Chiral Phosphorus Ligands for Practical Asymmetric Hydrogenation and Asymmetric Suzuki-Miyaura Coupling

The synthesis of P-chiral phosphorus ligands with novel structures is important for the development of efficient asymmetric catalytic transformations. Here, we describe the development of P-chiral phosphorus ligands such as BIBOP, WingPhos, BI-DIME, and 8 in our laboratory. Conformational rigidity,...

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Bibliographic Details
Published inSynlett Vol. 24; no. 19; pp. 2465 - 2471
Main Authors Liu, Guodu, Xu, Guangqing, Luo, Renshi, Tang, Wenjun
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 02.12.2013
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
cross-coupling
P-chiral phosphorus ligands
asymmetric catalysis
hydrogenation
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Summary:The synthesis of P-chiral phosphorus ligands with novel structures is important for the development of efficient asymmetric catalytic transformations. Here, we describe the development of P-chiral phosphorus ligands such as BIBOP, WingPhos, BI-DIME, and 8 in our laboratory. Conformational rigidity, high tunability of electronic and steric properties, and convenient physical properties are the main features of our ligand design. Progress in developing practical asymmetric hydrogenation and asymmetric cross-coupling reactions are discussed.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0033-1339875