Layered double hydroxide monolayers for controlled loading and targeted delivery of anticancer drugs

Two-dimensional （2D） nanomaterials have gained tremendous attention in the field of biomedicine because of their high specific surface areas and fascinating physicochemical properties. Herein, 2D monolayered double hydroxide （MLDH） nanosheets were employed to localize doxorubicin （DOX）, an anticance...

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Published inNano research Vol. 11; no. 1; pp. 195 - 205
Main Authors Mei, Xuan, Xu, Simin, Hu, Tongyang, Peng, Liuqi, Gao, Rui, Liang, Ruizheng, Wei, Min, Evans, David G., Duan, Xue
Format Journal Article
LanguageEnglish
Published Beijing Tsinghua University Press 2018
Subjects
Antineoplastic drugs
Antitumor agents
Atomic/Molecular Structure and Spectra
Biocompatibility
Biomedicine
Biotechnology
Cancer
Chemistry and Materials Science
Composite materials
Condensed Matter Physics
Doxorubicin
Drug delivery
Drug delivery systems
Electrostatic properties
Folic acid
In vitro methods and tests
Materials Science
Nanomaterials
Nanotechnology
Physicochemical properties
Research Article
双氢氧化物;装载能力;指向;控制;单层;交货;癌症治疗;物理化学
drug loading
layered double hydroxide (LDH)
monolayer
nanomaterials
two-dimensional
controllable release
Online AccessGet full text
ISSN1998-0124
1998-0000
DOI10.1007/s12274-017-1619-y

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Summary:Two-dimensional （2D） nanomaterials have gained tremendous attention in the field of biomedicine because of their high specific surface areas and fascinating physicochemical properties. Herein, 2D monolayered double hydroxide （MLDH） nanosheets were employed to localize doxorubicin （DOX）, an anticancer drug, with a loading capacity of as high as 3.6 mg.mg-1 （w/w）. Structural characterizations and theoretical calculations indicate that the DOX molecule is uniformly arranged and oriented at the surface of the MLDHs with a binding energy of 15.90 eV, showing significant electrostatic interaction. With the assistance of the targeting agent folic acid （FA）, DOX-FA/MLDHs demonstrate targeted cellular uptake and superior anticancer behavior based on in vitro tests performed with cancer cells. In addition, this composite material exhibits a selective release toward cancer cells and good biocompatibility with normal cells, which would guarantee its practical applications in cancer therapy.
Bibliography:Two-dimensional （2D） nanomaterials have gained tremendous attention in the field of biomedicine because of their high specific surface areas and fascinating physicochemical properties. Herein, 2D monolayered double hydroxide （MLDH） nanosheets were employed to localize doxorubicin （DOX）, an anticancer drug, with a loading capacity of as high as 3.6 mg.mg-1 （w/w）. Structural characterizations and theoretical calculations indicate that the DOX molecule is uniformly arranged and oriented at the surface of the MLDHs with a binding energy of 15.90 eV, showing significant electrostatic interaction. With the assistance of the targeting agent folic acid （FA）, DOX-FA/MLDHs demonstrate targeted cellular uptake and superior anticancer behavior based on in vitro tests performed with cancer cells. In addition, this composite material exhibits a selective release toward cancer cells and good biocompatibility with normal cells, which would guarantee its practical applications in cancer therapy.
11-5974/O4
two-dimensional,nanomaterials,monolayer,layered double hydroxide（LDH）,drug loading,controllable release
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ISSN:1998-0124
1998-0000
DOI:10.1007/s12274-017-1619-y