In vitro synergy with fluconazole plus doxycycline or tigecycline against clinical Candida glabrata isolates

Candida species, traditionally viewed as opportunistic agents, are increasingly seen as a cause of infection in hospitalized patients. Treatment options are limited to a few classes of drugs. Increased resistance, especially by Candida glabrata, is problematic. We investigated the interaction betwee...

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Bibliographic Details
Published inMedical mycology (Oxford) Vol. 57; no. 1; p. 122
Main Authors Hooper, Randol W, Ashcraft, Deborah S, Pankey, George A
Format Journal Article
LanguageEnglish
Published England 01.01.2019
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Summary:Candida species, traditionally viewed as opportunistic agents, are increasingly seen as a cause of infection in hospitalized patients. Treatment options are limited to a few classes of drugs. Increased resistance, especially by Candida glabrata, is problematic. We investigated the interaction between fluconazole and doxycycline or tigecycline, using clinically unique blood culture C. glabrata isolates. Eighteen isolates were screened using an Etest® MIC:MIC synergy method. With the doxycycline plus fluconazole combination, 28% of isolates showed synergy; tigecycline plus fluconazole showed 94% synergy. No antagonism was seen. The mechanisms of these interactions are unclear. Further research is warranted to assess clinical utility.
ISSN:1460-2709
DOI:10.1093/mmy/myy008