TiO2–Alginate–Chitosan-Based Composites for Skin Tissue Engineering Applications

The UV-B component of sunlight damages the DNA in skin cells, which can lead to skin cancer and premature aging. Therefore, it is necessary to use creams that also contain UV-active substances. Many sunscreens contain titanium dioxide due to its capacity to absorb UV-B wavelengths. In the present st...

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Published inGels Vol. 10; no. 6; p. 358
Main Authors Bobu, Emma, Saszet, Kata, Tóth, Zsejke-Réka, Páll, Emőke, Gyulavári, Tamás, Baia, Lucian, Magyari, Klara, Baia, Monica
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 22.05.2024
MDPI
Subjects
alginate
Alginates
Anatase
Apatite
Biomedical materials
Biopolymers
Body fluids
Calcium ions
Chitosan
Composite materials
hydrogel composites
Hydrogels
hydroxyapatite layer
In vitro methods and tests
Regeneration
Skin
Solar radiation
Spectrum analysis
Sun
Sun screens
Tissue engineering
Titanium
Titanium dioxide
Ultraviolet radiation
UV stability
Vibration
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Summary:The UV-B component of sunlight damages the DNA in skin cells, which can lead to skin cancer and premature aging. Therefore, it is necessary to use creams that also contain UV-active substances. Many sunscreens contain titanium dioxide due to its capacity to absorb UV-B wavelengths. In the present study, titan dioxide was introduced in alginate and chitosan–alginate hydrogel composites that are often involved as scaffold compositions in tissue engineering applications. Alginate and chitosan were chosen due to their important role in skin regeneration and skin protection. The composites were cross-linked with calcium ions and investigated using FT-IR, Raman, and UV–Vis spectroscopy. The stability of the obtained samples under solar irradiation for skin protection and regeneration was analyzed. Then, the hydrogel composites were assayed in vitro by immersing them in simulated body fluid and exposing them to solar simulator radiation for 10 min. The samples were found to be stable under solar light, and a thin apatite layer covered the surface of the sample with the two biopolymers and titanium dioxide. The in vitro cell viability assay suggested that the anatase phase in alginate and chitosan–alginate hydrogel composites have a positive impact.
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ISSN:2310-2861
2310-2861
DOI:10.3390/gels10060358