Preparation and characterization of antibacterial polyvinyl alcohol/chitosan sponge and potential applied for wound dressing

• Published in: European polymer journal Vol. 157; p. 110619
• Main Authors: Fan, Yao, Lu, Qiaohui, Liang, Wencheng, Wang, Youchang, Zhou, Yan, Lang, Meidong
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 15.08.2021; Elsevier BV
• Subjects: Antibacterial; Antimicrobial agents; Biocompatibility; Chitosan; DMAEMA; E coli; Elongation; Medical dressings; Polyvinyl alcohol; PVA; Sponges; Staphylococcus infections; Studies; Toxicity; Water absorption; Wound dressing; Wound healing; PVA; Wound dressing; Chitosan; Antibacterial; DMAEMA
• ISSN: 0014-3057; 1873-1945
• DOI: 10.1016/j.eurpolymj.2021.110619

Scheme 1. Synthesis of PVD, QPVD polymer and preparation of QPVDC wound dressing. [Display omitted] •The copolymer of polyvinyl alcohol grafted with DMAEMA was reported for the first time.•Excellent antibacterial characteristics of the sponges were obtained.•The CCK-8 assay indicated low-toxicity of the prepared sponge wound dressings. In this work, polyvinyl alcohol (PVA) with antimicrobial properties (QPVD), which were modified by 2-(Dimethylamino)ethyl methacrylate (DMAEMA) and 1-bromobutane. QPVD/chitosan (CS) composite sponge dressing (QPVDC) were prepared using freeze-drying process and cross-linked with glutaraldehyde vapor. Interestingly, compared with CS wound dressing, water absorption and flexibility of QPVDC wound dressing could be significantly improved with QPVD introduced. Among them, the water absorption of QPVDC sponge was up to 2300% and the elongation at break increased by 40–113%. In addition, QPVDC sponges with more quaternary ammonium could improve higher antibacterial activity, and the highest antibacterial activity of QPVDC sponges was close to 100% against E. coli and S. aureus. The results of hemolysis and cytotoxicity in vitro indicated that QPVDC wound dressing had excellent hemocompatibility and cytocompatibility. In summary, QPVDC wound dressing could protect from bacterial infection and accelerate wound healing. Thus, QPVDC had high potential application value for wound dressing.