The Hypercalcemia of Cancer Clinical Implications and Pathogenic Mechanisms

• Published in: The New England journal of medicine Vol. 310; no. 26; pp. 1718 - 1727
• Main Authors: Mundy, Gregory R, Ibbotson, Kenneth J, D'Souza, Sharyn M, Simpson, Ellen L, Jacobs, John W, Martin, T.John
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 28.06.1984
• Subjects: Animals; Biological and medical sciences; Bone Neoplasms - secondary; Bone Resorption; Cancer; Cancer therapies; Cells, Cultured; Colony-Stimulating Factors - physiology; Disease Models, Animal; Endocrinology; Growth factors; Hematologic and hematopoietic diseases; Humans; Hypercalcemia; Hypercalcemia - etiology; Immunoglobulins; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Leydig Cell Tumor - etiology; Lymphoma - complications; Male; Medical sciences; Metabolism; Metastasis; Multiple myeloma; Multiple Myeloma - complications; Neoplasms - complications; Osteoclasts - metabolism; Parathyroid Hormone - physiology; Patients; Peptides - physiology; Prostaglandins - physiology; Rats; Receptors, Cell Surface - metabolism; Receptors, Parathyroid Hormone; Testicular Neoplasms - etiology; Transforming Growth Factors; Tumors; Human; Hypercalcemia; Metabolic disorder; Prostaglandin; Parathyroid hormone; Arachidonic acid derivatives; Tumor; Malignant hemopathy; Inorganic element
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJM198406283102607

HYPERCALCEMIA is one of the most common metabolic complications of cancer. It has fascinated clinicians since it was first recognized 60 years ago by Zondek et al. 1 It is now being recognized more commonly, as is primary hyperparathyroidism, because of the advent of routine measurement of the serum calcium level. 2 , 3 The estimated incidence of the hypercalcemia of cancer is 150 new cases per million persons per year. 2 , 3 This compares with an annual incidence of approximately 250 new cases of primary hyperparathyroidism per year. 2 , 3 However, the relative frequency of cancer as a cause of hypercalcemia is even greater in hospital populations, . . .