Magnetic nanoparticles bearing metallocarbonyl moiety as antibacterial and antifungal agents

• Published in: Applied surface science Vol. 487; pp. 601 - 609
• Main Authors: Wilczewska, A.Z., Kosińska, A., Misztalewska-Turkowicz, I., Kubicka, A., Niemirowicz-Laskowska, K., Markiewicz, K.H., Bucki, R., Celichowski, G., Kalska-Szostko, B., Rudolf, B.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.09.2019
• Subjects: Antibacterial and antifungal agents; Magnetic nanoparticles; Metallocarbonyl complexes; Metallocarbonyl complexes; Antibacterial and antifungal agents; Magnetic nanoparticles
• ISSN: 0169-4332; 1873-5584
• DOI: 10.1016/j.apsusc.2019.05.159

Herein, is presented the synthesis and characterization of a new group of metallocarbonyl Fe, Ru, Mo, W complexes anchored to the surface of magnetic nanoparticles. Two types of iron oxide core-shell particles were employed to form complexes: containing amino or thiol groups at the surface. The metallocarbonyl complexes and complexes immobilized on magnetic particles were studied and compared in terms of their photostability. The obtained materials are promising antibacterial and antifungal agents as they appeared to be highly active against multidrug resistant Pseudomonas aeruginosa and flucytozyne resistant Candida albicans. [Display omitted] •Four different metallocarbonyl complexes (Fe, Ru, Mo, W) were immobilized on SH- and NH2-modified iron oxide particles.•Photodegradation process of the metallocarbonyl complex is slower when the complex is immobilized on magnetic nanoparticles.•CORMs anchored to magnetic particles are effective antibacterial and antifungal agents.