Radiobiology of ultrasoft X rays. II. Cultured C3H mouse cells (10T1/2)

• Published in: Radiation research Vol. 118; no. 1; p. 83
• Main Authors: Schillaci, M E, Carpenter, S, Raju, M R, Sebring, R J, Wilder, M E, Goodhead, D T
• Format: Journal Article
• Language: English
• Published: United States 01.04.1989
• Subjects: Animals; Cell Line; Cell Survival - radiation effects; Mice; Mice, Inbred C3H; Oxygen - physiology; Relative Biological Effectiveness
• ISSN: 0033-7587
• DOI: 10.2307/3577424

In the first paper of this series (Radiat. Res. 110, 396-412 (1987], using V79 cells, we reported that the relative biological effectiveness (RBE) of ultrasoft X rays was found to increase with decreasing energy, and the oxygen enhancement ratio (OER) was found to decrease with decreasing energy. In this report, we present RBE and OER results for 10T1/2 cells that are known to grow uniformly flat and are considerably thinner than V79 cells. Thus the variation in dose across the cell nucleus is considerably reduced. The OER results agree well with our earlier V79 results. However, the RBE values for 10T1/2 cells compared to V79 cells are systematically less for all soft X rays and especially for 0.28 keV carbon-K (1.3 compared to 3.4 for V79 cells). Some plausible explanations are presented to reconcile the apparent discrepancy between V79 and 10T1/2 results.