Ultrasensitive detection of Ebola matrix protein in a memristor mode

We demonstrate the direct biosensing of the Ebola VP40 matrix protein, using a memristor mode of a liquid-integrated nanodevice, based on a large array of honeycomb-shaped silicon nanowires. To shed more light on the principle of biodetection using memristors, we engineered the opening of the curren...

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Bibliographic Details
Published inNano research Vol. 11; no. 2; pp. 1057 - 1068
Main Authors Ibarlucea, Bergoi, Fawzul Akbar, Teuku, Kim, Kihyun, Rim, Taiuk, Baek, Chang-Ki, Ascoli, Alon, Tetzlaff, Ronald, Baraban, Larysa, Cuniberti, Gianaurelio
Format Journal Article
LanguageEnglish
Published Beijing Tsinghua University Press 01.02.2018
Springer Nature B.V
Subjects
Atomic/Molecular Structure and Spectra
Biomedicine
Biomolecules
Biosensors
Biotechnology
Chemistry and Materials Science
Condensed Matter Physics
Ebola virus
Ebolavirus
Electric potential
Field effect transistors
Honeycomb construction
Materials Science
Matrix protein
Memristors
Nanotechnology
Nanotechnology devices
Nanowires
Proteins
Research Article
Semiconductor devices
Voltage
VP40 protein
蛋白质;矩阵;电极设计;门电压;传感器;差距;晶体管;控制
VP40 matrix protein
capacitance
honeycomb nanowires
silicon nanowire field effect transistor
memristor biosensor
Ebola detection
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Summary:We demonstrate the direct biosensing of the Ebola VP40 matrix protein, using a memristor mode of a liquid-integrated nanodevice, based on a large array of honeycomb-shaped silicon nanowires. To shed more light on the principle of biodetection using memristors, we engineered the opening of the current-minima voltage gap VG by involving the third gap-control electrode （gate voltage, VG） into the system. The primary role of VG is to mimic the presence of the charged species of the desired sign at the active area of the sensor. We further showed the advantages of biodetection with an initially opened controlled gap （Vc~ ~a 0）, which allows the detection of the lowest concentrations of the biomolecules carrying arbitrary positive or negative charges; this feature was not present in previous configurations. We compared the bio-memristor performance, in terms of its detection range and sensitivity, to that of the already-known field-effect transistor （FET） mode by operating the same device. To our knowledge, this is the first demonstration of Ebola matrix protein detection using a nanoscaled electrical sensor.
Bibliography:memristor biosensor,capacitance,honeycomb nanowires,silicon nanowire fieldeffect transistor,VP40 matrix protein,Ebola detection
Bergoi Ibarlucea1＇2 , Teuku Fawzul Akbar1, Kihyun Kim, Taiuk Rim3, Chang-Ki Baek3, Alan Ascoli, Ronald Tetzlaff, Larysa Baraban1＇2 , and Gianaurelio Cuniberti（ Institute of Materials Science, Max Bergmann Center for Biomaterials, Technische Universit~ft Dresden, Budapester Str. 27, Dresden 01069, Germany 2 Center for Advancing Electronics Dresden （CFAED）, Technische Universit~t Dresden, Dresden 01069, Germany Department of Creative IT Engineering, Pohang University of Science and Technology, Pohang 37673, Republic of Korea 4 Chair of Fundamentals of Electrical Engineering, Technische Universit~t Dresden, MommsenstraBe 12, Dresden 01069, Germany）
11-5974/O4
We demonstrate the direct biosensing of the Ebola VP40 matrix protein, using a memristor mode of a liquid-integrated nanodevice, based on a large array of honeycomb-shaped silicon nanowires. To shed more light on the principle of biodetection using memristors, we engineered the opening of the current-minima voltage gap VG by involving the third gap-control electrode （gate voltage, VG） into the system. The primary role of VG is to mimic the presence of the charged species of the desired sign at the active area of the sensor. We further showed the advantages of biodetection with an initially opened controlled gap （Vc~ ~a 0）, which allows the detection of the lowest concentrations of the biomolecules carrying arbitrary positive or negative charges; this feature was not present in previous configurations. We compared the bio-memristor performance, in terms of its detection range and sensitivity, to that of the already-known field-effect transistor （FET） mode by operating the same device. To our knowledge, this is the first demonstration of Ebola matrix protein detection using a nanoscaled electrical sensor.
ISSN:1998-0124
1998-0000
DOI:10.1007/s12274-017-1720-2