Nanomaterials: an intra-periodontal pocket drug-delivery system for periodontitis

• Published in: Therapeutic delivery Vol. 14; no. 3; pp. 227 - 249
• Main Authors: Kumaar, Nethish R, Nair, Sreeja C
• Format: Journal Article
• Language: English
• Published: England Newlands Press Ltd 01.03.2023
• Subjects: anti-inflammatory; antimicrobial; Drug Delivery Systems; Gold; Humans; intra-periodontal pocket administration; Metal Nanoparticles; nano drug-delivery system; Periodontal Pocket - drug therapy; Periodontal Pocket - microbiology; periodontitis; Periodontitis - drug therapy; Periodontitis - microbiology; anti-inflammatory; antimicrobial; nano drug-delivery system; intra-periodontal pocket administration; periodontitis
• ISSN: 2041-5990; 2041-6008
• DOI: 10.4155/tde-2023-0001

Periodontitis is a microbiological condition that affects the tissues supporting the teeth. The fundamental to effective periodontal therapy is choosing the suitable antimicrobial and anti-inflammatory agent, together with the proper route of drug administration and delivery system. Intra-periodontal pocket approach with nano drug-delivery systems (NDDS) such as polymeric nanoparticles, gold nanoparticles, silica nanoparticles, magnetic nanoparticles, liposomes, polymersomes, exosomes, nano micelles, niosome, solid lipid nanoparticles, nano lipid carriers, nanocomposites, nanogels, nanofibers, scaffolds, dendrimers, quantum dots, etc., will be appropriate route of drug administration and delivery system. This NDDS delivers the drugs at the site of infection to inhibit growth and promote tissue regeneration. The present review focused on providing comprehensive information on the NDDS for periodontitis, which enhanced therapeutic outcomes via intra-periodontal pocket delivery. Periodontitis is a problem that can make your teeth fall out. It happens when the tissues that hold your teeth start to break down. Scientists have found a way to help treat it by using tiny things called ‘nano drug-delivery systems’ or NDDS. These NDDS carry medicine to the infected area and stop the germs from growing. They can also help the tissue around your teeth to heal. Some examples of NDDS are liposomes, polymersomes, exosomes, nanomicelles, and more. Regular treatment with antibiotics may not work as well as NDDS. Using NDDS can make a big difference in how well your teeth and gums heal. In the future, scientists hope to use NDDS to prevent the problem from coming back. This new way of treating periodontitis could be a big help for people with this problem. The nano drug-delivery system improves the targeting efficacy along with inhibition of microbial growth and initiates the tissue regeneration upon intra-periodontal delivery.