MARKER-DEPENDENT RECOMBINATION IN T4 BACTERIOPHAGE. II. THE EVALUATION OF MISMATCH REPAIRABILITIES IN CROSSES WITHIN INDICATOR DISTANCES

The contribution of mismatch repair to genetic recombination in T4 phage has been evaluated by three independent approaches: (1) testing for non-additivity of recombinant frequencies; (2) measurements of double exchange frequencies in three-factor crosses: (3) comparisons of recombination abilities...

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Published inGenetics (Austin) Vol. 102; no. 4; pp. 627 - 637
Main Authors Shcherbakov, V. P, Plugina, L. A, Kudryashova, E. A, Efremova, O. I, Sizova, S. T, Toompuu, Oleg G
Format Journal Article
LanguageEnglish
Published United States Genetics Soc America 01.12.1982
Subjects
Chromosome Mapping
DNA Repair
DNA, Viral - genetics
Genes, Viral
Genetic Linkage
Investigations
Recombination, Genetic
T-Phages - genetics
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Summary:The contribution of mismatch repair to genetic recombination in T4 phage has been evaluated by three independent approaches: (1) testing for non-additivity of recombinant frequencies; (2) measurements of double exchange frequencies in three-factor crosses: (3) comparisons of recombination abilities of mutations occupying the same site. Quantitative agreement among the results of these approaches suggests that within distances much less than the mean length of hybrid regions, mismatch repair accounts perfectly for high negative interference as measured in three-factor crosses and as manifested by non-additivity in two-factor crosses. The mismatch repair mechanism readily recognizes only particular mismatches, the repair frequency being dependent on the base sequence in both strands of the mismatched region.
Bibliography:ObjectType-Article-1
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ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1093/genetics/102.4.627