Serum calciprotein particle‐to‐phosphate ratio as a predictor of cardiovascular events in incident hemodialysis patients

• Published in: Therapeutic apheresis and dialysis Vol. 29; no. 2; pp. 178 - 188
• Main Authors: Akiyama, Tomoki, Iwazu, Yoshitaka, Usui, Joichi, Ebihara, Itaru, Ishizu, Takashi, Kobayashi, Masaki, Maeda, Yoshitaka, Kobayashi, Hiroaki, Yamagata, Kunihiro, Kuro‐o, Makoto, Yanagawa, Takamoto, Kobayashi, Tokuro, Ueda, Atsushi, Tsuchida, Makoto, Sakai, Shinichiro, Nakamura, Hideko, Takada, Kenji, Kozaki, Koichi, Iwabuchi, Satoshi, Iitsuka, Tadashi, Nishiki, Kenta, Takasaki, Hideaki, Takita, Takashi, Nakajima, Masami, Honma, Sumiko, Akai, Youichi, Ishizuka, Genzou, Issiki, Koichi, Saito, Takako, Iwamoto, Hitoshi, Ohishi, Akira, Ohtsuka, Masakazu, Ono, Atsushi, Kashiwabara, Hidehiko, Kanekawa, Takuro, Kanamori, Naoaki, Kaneda, Fumika, Kikuchi, Hiroshi, Kubo, Masashi, Kurosawa, Hiromi, Shiraishi, Takeshi, Shiigai, Tatsuo, Shima, Masayoshi, Takahashi, Tokuo, Matsukawa, Hideki, Tokoi, Minoru, Tsunematsu, Sadao, Tsuruta, Atsushi, Deguchi, Masao, Hayakawa, Masahiro, Hiroi, Makoto, Maeda, Nobuki, Hoshino, Takanobu, Yamaguchi, Tetsu, Yamada, Kota, Takeda, Atsushi, Takahashi, Ikuo, Yuhara, Takamichi, Kondo, Tadashi, Ooba, Syoji, Ogura, Yasunobu, Tachibana, Hisaya, Ookawa, Hiroshi, Fujii, Toshihiro
• Format: Journal Article
• Language: English
• Published: Kyoto, Japan John Wiley & Sons Australia, Ltd 01.04.2025
• Subjects: Aged; Biomarkers - blood; calciprotein particle; Cardiovascular Diseases - blood; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - etiology; dialysis initiation; Female; fibroblast growth factor‐23; Humans; Incidence; Male; Middle Aged; phosphate; Phosphates - blood; Renal Dialysis - adverse effects; Renal Dialysis - methods; Risk Factors; T50; Vascular Calcification - epidemiology; Vascular Calcification - etiology; phosphate; calciprotein particle; dialysis initiation; T50; fibroblast growth factor‐23
• ISSN: 1744-9979; 1744-9987; 1744-9987
• DOI: 10.1111/1744-9987.14203

Introduction Recent studies have identified increased blood calciprotein particle (CPP) levels as risk factors for vascular calcification and cardiovascular events in patients undergoing maintenance hemodialysis. Although positively correlated with serum phosphate levels, serum CPP levels vary considerably among patients with similar serum phosphate levels. We investigated the capacity of the ratio of serum CPP levels to serum phosphate levels (CPP/Pi ratio) to predict cardiovascular events in incident hemodialysis patients compared to the serum calcification propensity test (T50). Methods and Results The association between the CPP/Pi ratio and major adverse cardiac and cerebrovascular events (MACCE) was investigated in 174 incident hemodialysis patients. Multivariate analysis revealed that the CPP/Pi ratio was independently associated with MACCE [hazard ratio 1.60, 95% confidence interval (1.15–2.23), p = 0.006] but serum T50 levels were not. Conclusions The CPP/Pi ratio is a useful, novel biomarker for predicting the risk of cardiovascular events in patients undergoing incident hemodialysis.