Antifungal activity of propolis extract against Candida albicans in patients with vulvovaginal candidiasis [version 1; peer review: awaiting peer review]

• Published in: F1000 research Vol. 11; p. 1185
• Main Authors: Esteves Pairazaman, Ambrocio Teodoro, Collanque Pinto, Jesus Daniel, Alvarado Chávez, Britt, Leon Apac, Gabriel, Horna Sandoval, Consuelo Berta, Malpartida Quispe, Federico Martin, Collanque Meza, Vadir Ali Jesús, Ibarra Fretell, Walter Gregorio, Rodríguez Loyola, Gina Andrea
• Format: Journal Article
• Language: English
• Published: 2022
• Subjects: Vulvovaginal candidiasis; Antifungal activity; Propolis extract; Candida Albicans
• ISSN: 2046-1402; 2046-1402
• DOI: 10.12688/f1000research.125097.1

Background: The aim was to evaluate the antifungal activity of propolis extract against Candida albicans (or C. albicans) in patients with vulvovaginal candidiasis. Methods: The research presents a quantitative approach with an experimental design, with a population of C. albicans strains isolated from patients diagnosed with vulvovaginal candidiasis who were admitted to the Gynecology Service of the Maria del Socorro Clinic, district of Ate, Lima; a sample of 34 strains was chosen in total, considering three repetitions per strain, obtaining 102 experimental units. The antifungal susceptibility test was carried out by the disc diffusion plate method using a single concentration of propolis extract, with fluconazole as a positive control. Results: Propolis extract was shown to inhibit all strains of C. albicans, as was fluconazole, with the effect of the latter being significantly greater than that of the product under investigation. Conclusions: The conclusion is that propolis extract does show antifungal activity against C. albicans in patients with vulvovaginal candidiasis.