Mazindol Administration Improved Hyperphagia After Surgery for Craniopharyngioma Case Report

A 54-year-old man presented with visual disturbance and polydipsia. Magnetic resonance imaging disclosed a cystic mass which extended from the intrasellar to the suprasellar region. Bifrontal craniotomy was performed and the tumor was totally removed. Histological findings confirmed the diagnosis of...

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Published inNeurologia medico-chirurgica Vol. 41; no. 4; pp. 210 - 212
Main Authors SADATOMO, Takashi, SAKODA, Katsuaki, YAMANAKA, Masami, KUTSUNA, Munenori, KURISU, Kaoru
Format Journal Article
LanguageEnglish
Published Japan The Japan Neurosurgical Society 01.01.2001
Subjects
Appetite Depressants - therapeutic use
craniopharyngioma
Craniopharyngioma - diagnosis
Craniopharyngioma - surgery
Humans
hyperphagia
Hyperphagia - drug therapy
Hyperphagia - etiology
Male
mazindol
Mazindol - therapeutic use
Middle Aged
Postoperative Complications - drug therapy
Postoperative Complications - etiology
Supratentorial Neoplasms - diagnosis
Supratentorial Neoplasms - surgery
Treatment Outcome
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Summary:A 54-year-old man presented with visual disturbance and polydipsia. Magnetic resonance imaging disclosed a cystic mass which extended from the intrasellar to the suprasellar region. Bifrontal craniotomy was performed and the tumor was totally removed. Histological findings confirmed the diagnosis of craniopharyngioma. Postoperatively, the patient suffered from transient disorientation. About one month after the operation the patient manifested hyperphagia and he gained 15 kg in one month. Mazindol, a non-amphetaminergic anorectic agent, was administered for 3 weeks. His appetite normalized and his weight fell and stabilized even after mazindol administration was ceased.
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ISSN:0470-8105
1349-8029
DOI:10.2176/nmc.41.210