Diphtheria Antibodies and T lymphocyte Counts in Patients Infected With HIV-1

We assessed the IgG levels anti-diphtheria (D-Ab) and T cell counts (CD4+ and CD8+) in HIV-1 infected subjects undergoing or not highly active antiretroviral therapy (HAART). Approximately 70% of all HIV-1 patients were unprotected against diphtheria. There were no differences in D-Ab according to C...

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Published inBrazilian journal of microbiology Vol. 43; no. 3; pp. 946 - 950
Main Authors Speranza, Francisco A B, Ishii, Solange K, Thuler, Luiz C S, Damasco, Paulo V, Hirata, Jr, Raphael, Mattos-Guaraldi, Ana L, Milagres, Lucimar G
Format Journal Article
LanguageEnglish
Portuguese
Published Brazil Springer Nature B.V 01.07.2012
Sociedade Brasileira de Microbiologia
Subjects
Antiretroviral drugs
Diphtheria
HIV
Human immunodeficiency virus
Lymphocytes
MICROBIOLOGY
Vaccines
HIV-1
antibody to diphtheria toxin
vaccination
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Summary:We assessed the IgG levels anti-diphtheria (D-Ab) and T cell counts (CD4+ and CD8+) in HIV-1 infected subjects undergoing or not highly active antiretroviral therapy (HAART). Approximately 70% of all HIV-1 patients were unprotected against diphtheria. There were no differences in D-Ab according to CD4 counts. Untreated patients had higher D-Ab (geometric mean of 0.62 IU/ml) than HAART-patients (geometric mean of 0.39 IU/ml). The data indicated the necessity of keeping all HIV-1 patients up-to-date with their vaccination.
ISSN:1517-8382
1678-4405
1678-4405
DOI:10.1590/S1517-83822012000300014