Fulminant hepatitis due to reactivation of chronic hepatitis B virus infection after allogeneic bone marrow transplantation

A case of hepatitis B reactivation following bone-marrow transplantation for leukemia in a previously healthy HBsAg carrier is reported. A number of changes in HBV serum markers were contemporary to the acute episode. All of them (increase of HBsAg concentration, conversion from anti-HBe to HBeAg, a...

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Published inDigestive diseases and sciences Vol. 33; no. 9; p. 1185
Main Authors Pariente, E A, Goudeau, A, Dubois, F, Degott, C, Gluckman, E, Devergie, A, Brechot, C, Schenmetzler, C, Bernuau, J
Format Journal Article
LanguageEnglish
Published United States 01.09.1988
Subjects
Adult
Bone Marrow Transplantation
DNA Replication
Female
Hepatitis B - immunology
Hepatitis B - microbiology
Hepatitis B Surface Antigens - analysis
Hepatitis B virus - physiology
Heterozygote
Humans
Immunosuppression - adverse effects
Leukemia, Myeloid - therapy
Virus Replication
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Summary:A case of hepatitis B reactivation following bone-marrow transplantation for leukemia in a previously healthy HBsAg carrier is reported. A number of changes in HBV serum markers were contemporary to the acute episode. All of them (increase of HBsAg concentration, conversion from anti-HBe to HBeAg, appearance of anti-HBc IgM and of serum HBV-DNA) were suggestive of a "switching-on" of viral replication. Institution of corticosteroid treatment at the onset of the acute phase did not prevent the fatal outcome.
ISSN:0163-2116
DOI:10.1007/BF01535798