Subject: Acknowledgement of letter regarding “Leukadherin-1 mitigates disseminated intravascular coagulation in acute pancreatitis by suppressing necroptosis”

•LA-1 inhibits RIPK1 phosphorylation, may potentially disrupting the intersection between necroptotic and pyroptotic signaling pathways, which needs further experimental validation.•Further investigations including knockout mice will be done to elucidate the underlying precise molecular mechanisms o...

Full description

Saved in:
Bibliographic Details
Published inThrombosis research p. 109388
Main Authors Yi, Zhongjie, Xu, Xueming, Xiang, Xingyu, Chang, Jinyuan, Shi, Jie, Wang, Yongjun
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 28.06.2025
Subjects
Hematology, Oncology, and Palliative Medicine
Online AccessGet full text

Cover

More Information
Summary:•LA-1 inhibits RIPK1 phosphorylation, may potentially disrupting the intersection between necroptotic and pyroptotic signaling pathways, which needs further experimental validation.•Further investigations including knockout mice will be done to elucidate the underlying precise molecular mechanisms of LA-1.•The mice model is reliable and safety of LA-1 on human and long-term effect will be examined in our coming studies.
Bibliography:content type line 23
SourceType-Scholarly Journals-1
ObjectType-Correspondence-1
ISSN:0049-3848
1879-2472
1879-2472
DOI:10.1016/j.thromres.2025.109388