Radiation cytogenetics: from chromosomes to single nucleotides and from metaphase cells to tissues

This paper provides a broad overview of radiation cytogenetics that is divided into four sections. The first section provides a brief history of metaphase-based analyses for detecting and quantifying human exposure to ionizing radiation. The second section describes technologies for detecting cellul...

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Bibliographic Details
Published inCancer and metastasis reviews Vol. 23; no. 3-4; pp. 341 - 349
Main Author Tucker, James D
Format Journal Article
LanguageEnglish
Published Netherlands Springer Nature B.V 01.08.2004
Subjects
Animals
Chromosomes - radiation effects
Cytogenetics
DNA Damage - radiation effects
Humans
Metaphase - radiation effects
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Nucleotides - metabolism
Nucleotides - radiation effects
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Summary:This paper provides a broad overview of radiation cytogenetics that is divided into four sections. The first section provides a brief history of metaphase-based analyses for detecting and quantifying human exposure to ionizing radiation. The second section describes technologies for detecting cellular responses to radiation exposure other than DNA damage. The third section discusses molecular cytological approaches for analyzing some of the long-term effects of radiation exposure in tissues, including tumors. The final section provides a look towards the future and makes recommendations including suggestions for technological innovations that would enhance the field of radiation cytology.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0167-7659
1573-7233
DOI:10.1023/B:CANC.0000031772.30799.25