Molecular physiology of proton transduction in nociceptors

Recent cloning efforts have identified families of ion channels that may be involved in signaling noxious proton accumulation in tissue. Some conduct potassium ions outward and are closed by excess protons, others are opened under this condition carrying cations inward and their putative function is...

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Published inCurrent Opinion in Pharmacology Vol. 1; no. 1; pp. 45 - 51
Main Authors Reeh, Peter W, Kress, Michaela
Format Book Review Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.2001
Subjects
Acid sensing
Animals
Capsaicin
Capsaicin - pharmacology
Humans
Hydrogen-Ion Concentration
Inflammation
Ion Channel Gating - drug effects
Ion Channel Gating - physiology
Ion Channels - physiology
Mice
Mice, Knockout
Nociception
Nociceptors - chemistry
Nociceptors - physiology
Peripheral
Potassium Channels - drug effects
Protons
Receptors, Drug - drug effects
Sensory
Signal Transduction - physiology
Transduction
Protons
Nociception
Peripheral
Capsaicin
Transduction
Inflammation
Sensory
Acid sensing
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Summary:Recent cloning efforts have identified families of ion channels that may be involved in signaling noxious proton accumulation in tissue. Some conduct potassium ions outward and are closed by excess protons, others are opened under this condition carrying cations inward and their putative function is in their name (‘acid sensing’), and again another channel is truly polymodal, the capsaicin receptor, sensing acid and heat. Further heat-activated channels, not yet cloned, may not be gated by protons but sensitized so strongly that they open at the command of body temperature. In either case, the result may be pain from tissue acidosis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1471-4892
1471-4973
DOI:10.1016/S1471-4892(01)00014-5