A comparison between chlordiazepoxide and CL 218,872--a synthetic nonbenzodiazepine ligand for benzodiazepine receptors on spontaneous locomotor activity in rats

Spontaneous locomotor activity was investigated in rats treated with chlordiazepoxide (CDP) or CL 218,872, a synthetic nonbenzodiazepine ligand for benzodiazepine receptors. Acute administration of CDP (2.5 mg/kg) increased activity, whereas a higher dose (10 mg/kg) decreased activity. Acute injecti...

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Bibliographic Details
Published inPsychopharmacology Vol. 85; no. 2; p. 224
Main Authors McElroy, J F, Fleming, R L, Feldman, R S
Format Journal Article
LanguageEnglish
Published Germany 01.01.1985
Subjects
Animals
Anti-Anxiety Agents - pharmacology
Chlordiazepoxide - pharmacology
Drug Tolerance
Male
Motor Activity - drug effects
Pyridazines - pharmacology
Rats
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Summary:Spontaneous locomotor activity was investigated in rats treated with chlordiazepoxide (CDP) or CL 218,872, a synthetic nonbenzodiazepine ligand for benzodiazepine receptors. Acute administration of CDP (2.5 mg/kg) increased activity, whereas a higher dose (10 mg/kg) decreased activity. Acute injection of CL 218,872 (2.5-10 mg/kg) produced a significant dose-dependent suppression of locomotor activity, a finding at variance with a previous report that anxiolytic doses of CL 218,872 are devoid of depressant side effects. Chronic pretreatment with CDP or CL 218,872 (10 mg/kg daily for 6 days) produced a tolerance to the sedative effect of CDP (10 mg/kg), but not to the activity suppressant action of CL 218,872 (10 mg/kg).
ISSN:0033-3158
DOI:10.1007/BF00428419