Effect of richlocaine alone or in combination with energostim on the severity of endotoxemia and survival of the skin under conditions of reduced blood flow

• Published in: Bulletin of experimental biology and medicine Vol. 136; no. 3; pp. 253 - 256
• Main Authors: Zadorozhnyi, A V, Popkov, V L, Galenko-Yaroshevskii, V P, Antelava, A V, Chikobava, E A, Sukoyan, G V, Meladze, V N
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01.09.2003
• Subjects: Alanine Transaminase - metabolism; Animals; Antioxidants - pharmacology; Aspartate Aminotransferases - metabolism; Cell Survival; Cytochromes c - pharmacology; Drug Combinations; Endotoxemia - drug therapy; Endotoxemia - metabolism; Erythrocytes - metabolism; Histamine - metabolism; Hydroxyproline - chemistry; Hypoxia; Inflammation; Inosine - pharmacology; Keratinocytes - metabolism; Lactates - metabolism; Male; NAD - pharmacology; Necrosis; Piperidines - pharmacology; Rats; Regional Blood Flow; Serotonin - metabolism; Skin - drug effects; Skin - pathology; Surgical Flaps - pathology; Time Factors; Vasodilator Agents - pharmacology
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1023/B:BEBM.0000008976.49593.9c

The local anesthetic richlocaine decreased the area of necrosis in the skin flap under conditions of reduced blood flow by 29.5%. Improved survival of skin flap after richlocaine treatment alleviated endogenous intoxication, reduced secondary inflammatory reaction, improved liver function, and normalized the ratio between vasoconstricting and vasodilating prostaglandins. This effect was most pronounced after combination therapy with richlocaine and direct-action antihypoxant energostim.